Recombinant Bovine IL1B Protein, Tag Free
Product Description
Cat
IMP-7101
Official Symbol
IL1B
Product Overview
Recombinant bovine Interleukin-1 beta/IL-1B protein without tag was expressed in Pichia pastoris.
Description
Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Expression System
Yeast
Species
Bovine
Tag
Tag free
Form
Presentation State: Purified
State: Lyophilised
Buffer System: PBS.
Molecular Mass
17.7 kDa
Purity
> 95% by SDS-PAGE.
Applications
Functional Assays
Storage
Prior to reconstitution store at 2-8 centigrade. Following reconstitution store the protein undiluted at -70 centigrade. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Reconstitution
Restore with 0.5 ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. We recommend that the vial is gently mixed after reconstitution.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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