Recombinant Cynomolgus CD28 Protein, C-hFc-tagged
Product Description
Cat
IMP-1607
Official Symbol
CD28
Product Overview
Recombinant cynomolgus CD28 [(Identical to the rhesus CD28 (NP_001036106.2)] (Met1-Pro152) was expressed with the Fc region of human IgG1 at the C-terminus.
Description
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Expression System
HEK293
Species
Cynomolgus
Tag
C-hFc
Predicted N Terminal
Asn 19
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant cynomolgus CD28 consists 372 amino acids and predicts a molecular mass of 41.9 kDa.
Protein length
Met1-Pro152
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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