Description
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
Molecular Mass
Predicted Molecular Mass: 38 kDa (alpha chain), 23 kDa (beta chain), 61 kDa (full length)
SDS-PAGE: 65-90 kDa, under non-reducing conditions
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human FGF basic/FGF2 (146aa) is immobilized at 0.5 μg/mL (100 μL/well), Recombinant Cynomolgus Monkey/Rhesus Macaque Glypican 3 His-tag binds with an ED50 of 0.075-0.45 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
