IMP-9164

ACVR1

Human ACVR1 (NP_001096.1, 145 a.a.-509 a.a.) partial recombinant protein with GST tag was expressed in Baculovirus infected Sf21 cells.

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Insect cells

Human

GST

Liquid, In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol)

69 kDa

145-509

82 % by SDS-PAGE/CBB staining

Functional Study; SDS-PAGE

Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

SDS-PAGE Stained with Coomassie Blue