Recombinant Human ACVR1 Protein (145-509), N-GST-tagged
Product Description
Cat
IMP-9165
Official Symbol
ACVR1
Product Overview
Human ACVR1 (NP_001096.1, 145 a.a.-509 a.a.) Q207D mutant partial recombinant protein with GST-tag at N-terminal using baculovirus expression system.
Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Expression System
Viruses
Species
Human
Tag
N-GST
Form
Liquid, 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
Protein length
145-509
Purity
0.94
Applications
Functional Study
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Bioactivity-ELISA 1
Result of activity analysis

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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