Recombinant Human ACVR1B Protein (Leu32-Glu126), C-Fc and 6×His-tagged
Product Description
Cat
IMP-10187
Official Symbol
ACVR1B
Product Overview
Recombinant human Activin RIB/ALK-4 protein (Leu32-Glu126) with human IgG1 (Pro100-Lys330) Fc tag and 6×His tag was expressed in Mouse myeloma cell line
Description
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Expression System
Mouse myeloma cell line
Species
Human
Tag
C-Fc and 6×His
Predicted N Terminal
Leu32
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 37.5 kDa (monomer)
SDS-PAGE: 45-50 kDa, reducing conditions
Protein length
Leu32-Glu126
Bio-activity
Measured by its binding ability in a functional ELISA. Immobilized rhActivin RIB/Fc Chimera at 2 μg/mL (100 μL/well) can bind rhCripto with a linear range of 0.8-100 ng/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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