Product Overview
Purified recombinant protein of Human activin A receptor type II-like 1 (ACVRL1), transcript variant 1, Asp22-Leu119, with N-terminal His-ABP tag, expressed in E. coli.
Description
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Form
25mM Tris, pH 8.0, 150mM NaCl, 10% glycerol
