Recombinant Human ADK Protein (Ala2-His362), C-6×His-tagged
Product Description
Cat
IMP-10650
Official Symbol
ADK
Product Overview
Recombinant human Adenosine Kinase/ADK protein (Ala2-His362) with a C-terminal 6×His tag was expressed in E. coli.
Description
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Expression System
E. coli
Species
Human
Tag
C-6×His
Predicted N Terminal
Ala2
Form
Supplied as a 0.2 μm filtered solution in Tris and NaCl.
Molecular Mass
Predicted Molecular Mass: 41 kDa
SDS-PAGE: 43-45 kDa, reducing conditions
Protein length
Ala2-His362
Bio-activity
Measured by its ability to phosphorylate Adenosine. The specific activity is >7 pmol/min/μg, as measured under the described conditions.
Endotoxin
<1.0 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
6 months from date of receipt, -70 centigrade as supplied.
3 months, -70 centigrade under sterile conditions after opening.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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