Recombinant Human AXL Protein (Glu33-Pro440), C-Fc and 6×His-tagged
Product Description
Cat
IMP-10181
Official Symbol
AXL
Product Overview
Recombinant human Axl protein (Glu33-Pro440) with a human IgG1 (Pro100-Lys330) Fc tag and 6×His tag at C-terminus was expressed in Mouse myeloma cell line.
Description
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
Expression System
Mouse myeloma cell line
Species
Human
Tag
C-Fc and 6×His
Predicted N Terminal
Glu33
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 71.7 kDa (monomer)
SDS-PAGE: 100-110 kDa, reducing conditions
Protein length
Glu33-Pro440
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human Axl Fc Chimera is immobilized at 2 μg/mL (100 μL/well), the concentration of Recombinant Human Gas6 that produces 50% of the optimal binding response is approximately 2.5-15 ng/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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