Product Overview
Recombinant protein of human Bruton agammaglobulinemia tyrosine kinase (BTK), full length, with C-terminal polyhistidine tag, expressed in sf9 cell.
Description
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
