Product Overview
Human CD244 (NP_057466.1, 22 a.a.-221 a.a.) partial recombinant protein with Fc, 6x His tag at C-terminal expressed in HEK293 cells.
Description
Natural killer (NK) cells express both activating and inhibitory cell surface receptors. Inhibitory signaling receptors all possess cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, or ITIMs, whereas the activating receptors lack ITIMs and associate with DAP12, which contains an immunoreceptor tyrosine-based activation motif, or ITAM. Killer cell immunoglobulin (Ig)-like receptors, or KIRs, and other NK cell receptors interact with major histocompatibility complex (MHC) molecules. Members of the CD2 family adhere to each other instead. The cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function.
Storage
Store the lyophilized protein at -20 to -80 centigrade for long term. After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20 centigrade for 3 months, at 2-8 centigrade for up to 1 week. Aliquot to avoid repeated freezing and thawing.
