Recombinant Human CD274 Protein (Phe19-Thr239), C-His-tagged
Product Description
Cat
IMP-7418
Official Symbol
CD274
Product Overview
Purified recombinant protein of Human PD-L1 / CD274 molecule (PD-L1 / CD274) with a C-His tag was expressed in HEK293.
Description
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression System
HEK293
Species
Human
Tag
C-His
Form
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.
Molecular Mass
26.33 kDa
Protein length
Phe19-Thr239
Endotoxin
< 0.1 ng/μg
Purity
> 95% as determined by SDS-PAGE and Coomassie blue staining
Storage
Store at -80 centigrade.
Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

Online Inquiry
Contact Info