Description
Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome.
Bio-activity
Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 for this effect is 0.2-1.4 μg/mL. Measured by its binding ability in a functional ELISA. When Human Siglec-3/CD33 (6C5/2) Antibody is immobilized at 0.5 μg/mL (100 μL/well), Biotinylated Recombinant Human Siglec-3/CD33 Fc Chimera binds with an ED50 of 0.15-1.2 ng/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
