Description
Cluster of Differentiation 34 (CD34) is a member of a family of single-pass transmembrane sialomucin proteins, and may function as a cell-cell adhesion factor. CD34 protein is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. It has been widely used as a stem and progenitor cell marker, and clinical CD34+ stem cell transplantation (CD34+SCT) has been performed for tumor purging. CD34 monoclonal antibodies are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias.
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human CD34/Fc is a disulfide-linked homodimer generated after removal of the signal peptide. The reduced monomer consists of 497 amino acids and has a predicted molecular mass of 54 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is 116 and 96 kDa due to different glycosylation.
