Recombinant Human CD3E Protein (Gln22-Asp126), C-hFc-tagged
Product Description
Cat
IMP-10386
Official Symbol
CD3E
Product Overview
Recombinant human CD3 epsilon protein (Gln22-Asp126) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Human embryonic kidney cell.
Description
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Expression System
HEK293
Species
Human
Tag
C-hFc
Predicted N Terminal
No results obtained. Gln22 inferred from enzymatic pyroglutamate treatment revealing Asp23.
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 38 kDa
SDS-PAGE: 40-57 kDa, reducing conditions
Protein length
Gln22-Asp126
Bio-activity
Bioassay data are not available.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Disulfide-linked homodimer
Storage
12 months from date of receipt, ≤ -20 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 500 μg/mL in PBS.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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