Recombinant Human CD86 Protein (24-246), N-His/Flag/StrepII-tagged
Product Description
Cat
IMP-9242
Official Symbol
CD86
Product Overview
Purified CD86 (AAH40261.1, 24 a.a.-246 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus was expressed in human HEK293T cells.
Description
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Expression System
HEK293T
Species
Human
Tag
N-His/Flag/StrepII
Form
Liquid, 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Molecular Mass
29.81 kDa
Protein length
24-246
AA Sequence
APLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHI
Applications
WB; ELISA; SDS-PAGE; Protein Interaction
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration
≥ 10 μg/mL
SDS-PAGE
Quality Control Testing

SDS-PAGE

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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