Recombinant Human CD86 Protein (24-246), N-His/Flag/StrepII-tagged
Product Description
Cat
IMP-9242
Official Symbol
CD86
Product Overview
Purified CD86 (AAH40261.1, 24 a.a.-246 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus was expressed in human HEK293T cells.
Description
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
Expression System
HEK293T
Species
Human
Tag
N-His/Flag/StrepII
Form
Liquid, 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Molecular Mass
29.81 kDa
Protein length
24-246
AA Sequence
APLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGIMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHI
Applications
WB; ELISA; SDS-PAGE; Protein Interaction
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration
≥ 10 μg/mL
SDS-PAGE
Quality Control Testing

SDS-PAGE

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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