Product Overview
Recombinant human CDA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Description
CDA (Cytidine deaminase) is an enzyme that scavenges exogenous and endogenous cytidine and 2- deoxycytidine for uMP synthesis. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. The protein also catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. It can form homotetramers and is mainly expressed in granulocytes.
Form
Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 2mM EDTA, 100mM NaCl, 40% glycerol
