Recombinant Human CLDN18 Protein, Tag free
Product Description
Cat
IMP-7870
Official Symbol
CLDN18
Product Overview
Human CLDN18 (P56856-2, 1 a.a.-261 a.a.) full-length recombinant protein was expressed in 293 cells.
Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Expression System
HEK293
Species
Human
Tag
Tag free
Form
Liquid, In 20 mM PB, 500 mM NaCl, pH 7.0 (10% glycerol, 0.025% DDM, 0.005% CHS)
Molecular Mass
27.8 kDa
Protein length
1-261
AA Sequence
MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV
Endotoxin
< 0.2 EU/μg of protein (determined by gel clotting method)
Purity
> 75% by SDS-PAGE
Applications
Functional Study; SDS-PAGE
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
SDS-PAGE
Quality Control Testing

2 μg protein in Reducing condition, no heat treatment before loading and Non-Reducing condition SDS-PAGE Stained with Coomassie Blue

Bioactivity-ELISA 1
Result of bioactivity analysis

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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