Product Overview
Recombinant human CTLA-4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description
CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. It also is a protein receptor that functions as an immune checkpoint and downregulates immune responses. This protein is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation a phenomenon which is particularly notable in cancers. It may also function via modulation of cell motility and signaling through PI3 kinase. It has been implicated in several autoimmune diseases, such as systemic lupus erythematosus.
