Recombinant Human CTLA4 Protein (37-161), N-His/Flag/StrepII-tagged
Product Description
Cat
IMP-8012
Official Symbol
CTLA4
Product Overview
Purified CTLA4 (AAH74842.1, 37 a.a.-161 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus was expressed in human HEK293H cells.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
HEK293H
Species
Human
Tag
N-His/Flag/StrepII
Form
Liquid, 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Molecular Mass
19.03 kDa
Protein length
37-161
AA Sequence
AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSD
Applications
WB; ELISA; SDS-PAGE; Protein Interaction
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration
≥ 10 μg/mL
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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