Recombinant Human CTLA4 Protein (37-161), N-His/Flag/StrepII-tagged
Product Description
Cat
IMP-8012
Official Symbol
CTLA4
Product Overview
Purified CTLA4 (AAH74842.1, 37 a.a.-161 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus was expressed in human HEK293H cells.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
HEK293H
Species
Human
Tag
N-His/Flag/StrepII
Form
Liquid, 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Molecular Mass
19.03 kDa
Protein length
37-161
AA Sequence
AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSD
Applications
WB; ELISA; SDS-PAGE; Protein Interaction
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration
≥ 10 μg/mL
Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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