Recombinant Human CTLA4 Protein (37-162), C-hFc-tagged
Product Description
Cat
IMP-8009
Official Symbol
CTLA4
Product Overview
Human CTLA4 (P16410, 37 a.a.-162 a.a.) partial recombinant protein with hFc tag at C-terminus was expressed in CHO cell.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
CHO
Species
Human
Tag
C-hFc
Form
Lyophilized from sterile distilled Water up to 100 μg/mL
Molecular Mass
45-48 kDa
Protein length
37-162
AA Sequence
AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDF
Endotoxin
< 0.2 EU/μg of protein (determined by gel clotting method)
Purity
> 98% by SDS-PAGE
Applications
Functional Study; SDS-PAGE
Storage
Store at 4 to 8 centigrade for 1 week. For long term storage store at -20 to -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

Online Inquiry
Contact Info
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  • 1-631-559-9269
    1-516-512-3133
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