Recombinant Human CTLA4 Protein (37-162), C-hFc-tagged
Product Description
Cat
IMP-8009
Official Symbol
CTLA4
Product Overview
Human CTLA4 (P16410, 37 a.a.-162 a.a.) partial recombinant protein with hFc tag at C-terminus was expressed in CHO cell.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
CHO
Species
Human
Tag
C-hFc
Form
Lyophilized from sterile distilled Water up to 100 μg/mL
Molecular Mass
45-48 kDa
Protein length
37-162
AA Sequence
AMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDF
Endotoxin
< 0.2 EU/μg of protein (determined by gel clotting method)
Purity
> 98% by SDS-PAGE
Applications
Functional Study; SDS-PAGE
Storage
Store at 4 to 8 centigrade for 1 week. For long term storage store at -20 to -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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