Recombinant Human CTLA4 Protein (Ala37-Phe162), Fc-tagged
Product Description
Cat
IMP-7510
Official Symbol
CTLA4
Product Overview
Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1 with Fc tag was expressed in CHO.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
CHO
Species
Human
Tag
Fc
Form
1×PBS
Molecular Mass
39.9 kDa
Protein length
Ala37-Phe162
Endotoxin
< 0.01 ng/μg protein as determined by the LAL method
Purity
> 95% as determined by Coomassie stained SDS-PAGE.
Storage
Store at -80 centigrade.
Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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