Recombinant Human CTLA4 Protein (Gln36-Ser161), C-hFc-tagged
Product Description
Cat
IMP-7514
Official Symbol
CTLA4
Product Overview
Recombinant Human CTLA-4 Protein with a C-Human Fc (Glu99-Ala330) tag was expressed in HEK293.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
HEK293
Species
Human
Tag
C-hFc
Form
Lyophilized from sterile PBS, pH 7.4. Normally 5-8 % trehalose is added as protectants before lyophilization.
Molecular Mass
39.6 kDa
Protein length
Gln36-Ser161
Purity
> 95%
Applications
FC
Storage
Store the lyophilized protein at -20 centigrade. After reconstitution, store the protein at -80 centigrade for 12 months. Avoid repeated freezing and thawing.
Stability: 12 months from date of despatch.
Reconstitution
Reconstitute with deionized water.
SDS-PAGE
SDS-PAGE

Bioactivity-ELISA 1
Bioactivity

Bioactivity-FACS 1
Bioactivity

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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