Recombinant Human CTLA4 Protein (Lys36-Asp161), C-Fc-tagged
Product Description
Cat
IMP-7512
Official Symbol
CTLA4
Product Overview
Purified recombinant protein of Human cytotoxic T-lymphocyte-associated protein 4 (CTLA4), transcript variant 1 with a C-Fc tag was expressed in HEK293.
Description
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Expression System
HEK293
Species
Human
Tag
C-Fc
Form
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4
Molecular Mass
41.5 kDa
Protein length
Lys36-Asp161
Endotoxin
< 0.1 ng/μg
Purity
> 95% as determined by SDS-PAGE and Coomassie blue staining
Storage
Store at -80 centigrade.
Stability: Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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