Description
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human LRP-6 Fc Chimera is immobilized onto a Goat anti-Human IgG Fc antibody coated plate, the concentration of Recombinant Human Dkk-1 C-Terminal Fragment that produces 50% optimal binding response is 60-360 ng/mL.
Storage
12 months from date of receipt, ≤ -20 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
