Product Overview
Recombinant human DuT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Description
DuT, also known as duTP pyrophosphatase, is a ubiquitous enzyme that functions in nucleotide metabolism. This protein, in the presence of magnesium ions, is responsible for hydrolyzing duTP to duMP and diphosphate. This reaction is important for keeping the intracellular duTP concentration low so that uracil does not become incorporated into DNA. Extensive incorporation of uracil into DNA can ultimately lead to cell death. This suggests that DuT is essential for cell viability, further implying that it is a potential target for anticancer therapy.
