Recombinant Human EPHA8 Protein (Glu31-Thr542), C-hFc-tagged
Product Description
Cat
IMP-9866
Official Symbol
EPHA8
Product Overview
Recombinant human EphA8 protein (Glu31-Thr542) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.
Description
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
Expression System
Mouse myeloma cell line
Species
Human
Tag
C-hFc
Predicted N Terminal
Glu31
Form
Supplied as a 0.2 μm filtered solution in MES, NaCl, PEG, CHAPS and Imidazole.
Molecular Mass
Predicted Molecular Mass: 83.2 kDa (monomer)
SDS-PAGE: 94 kDa, reducing conditions
Protein length
Glu31-Thr542
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human EphA8 Fc Chimera is coated at 2 μg/mL (100 μL/well), the concentration of Biotinylayed Recombinant Human Ephrin-A5 Fc Chimera that produces 50% of the optimal binding response is 2-12 ng/mL.
Endotoxin
<0.01 EU/μg of the protein by the LAL method.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after opening.
3 months, -20 to -70 centigrade under sterile conditions after opening.
Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

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    1-516-512-3133
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