Recombinant Human ERBB4 Protein (676-562), GST-tagged
Product Description
Cat
IMP-8119
Official Symbol
ERBB4
Product Overview
Human ERBB4 (NP_005226.1, 676 a.a.-562 a.a.) full-length recombinant protein with GST tag was expressed in Baculovirus infected Sf21 cells.
Description
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Expression System
Insect cells
Species
Human
Tag
GST
Form
Liquid, In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol)
Molecular Mass
99 kDa
Protein length
676-562
Purity
73 % by SDS-PAGE/CBB staining
Applications
Functional Study; SDS-PAGE
Storage
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
SDS-PAGE
Quality Control Testing

Loading 1 μg protein in SDS-PAGE

Bioactivity-ELISA 1
Result of activity analysis

Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

Online Inquiry
Contact Info
Phone
  • 1-631-559-9269
    1-516-512-3133
Fax
  • 1-631-938-8127
Email
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