Description
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Bio-activity
Measured by its binding ability in a functional ELISA. When Normal Human IgG is immobilized at 10 μg/mL (100 μL/well), the concentration of Biotinylated Recombinant Human Fc gamma RIIB/C (CD32b/c) His-tag Avi-tag that produces 50% of the optimal binding response is found to be approximately 0.5-3.0 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -70 centigrade under sterile conditions after reconstitution.
