Description
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor.
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human IFN-alpha/beta R1 is present at 1 μg/mL, it binds to Recombinant Human IFN-alpha/beta R2 Fc Chimera in the presence of recombinant human IFN-alpha 2. The concentration of Recombinant Human IFN-alpha/beta R2 Fc Chimera that produces 50% of the optimal binding response is approximately 0.5-1.5 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
