Recombinant Human IGF1R Protein (Met1-Asn932)

Product Description

Cat

IMP-10425

Official Symbol

IGF1R

Product Overview

Recombinant human IGF-I R/IGF1R protein (Met1-Asn932) without tag was expressed in Mouse myeloma cell line.

Description

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Expression System

Mouse myeloma cell line

Species

Human

Tag

Tag Free

Predicted N Terminal

Glu31 and Asp741

Form

Lyophilized from a 0.2 μm filtered solution in PBS.

Molecular Mass

Predicted Molecular Mass: 102.9 kDa (single chain); 81.0 kDa (alpha chain) & 21.9 kDa (beta chain)
SDS-PAGE: 160 kDa, 125 kDa, 50 kDa & 40 kDa, reducing conditions

Protein length

Met1-Asn932

Bio-activity

Measured by its ability to bind human IGF-I R/IGF1R in a functional ELISA.

Endotoxin

<0.10 EU/μg of the protein by the LAL method.

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Data Sheet MSDS

Datasheet MSDS

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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