Recombinant Human IL10 Protein (Ser19-Asn178), Tag Free
Product Description
Cat
IMP-7645
Official Symbol
Il10
Product Overview
Purified recombinant protein of Human interleukin 10 (IL10) without tag was produced in HEK293.
Description
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
Expression System
HEK293
Species
Human
Tag
Tag free
Form
1×PBS
Molecular Mass
18.6 kDa
Protein length
Ser19-Asn178
Endotoxin
< 0.01 ng/μg protein as determined by the LAL method
Purity
> 95% as determined by Coomassie stained SDS-PAGE.
Storage
Store at -80 centigrade.
Stability: Unopened vial can be stored between 2 and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Concentration
lot specific
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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