Recombinant Human IL13RA1 Protein (Ala27-Thr343, Thr130Ile), C-hFc and 6×His-tagged
Product Description
Cat
IMP-10499
Official Symbol
IL13RA1
Product Overview
Recombinant human IL-13 R alpha 1 protein (Ala27-Thr343, Thr130Ile) with Human IgG1 (Pro100-Lys330) Fc tag and 6×His tag at C-terminus was expressed in Mouse myeloma cell line.
Description
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Expression System
Mouse myeloma cell line
Species
Human
Tag
C-hFc and 6×His
Predicted N Terminal
Ala27
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 64 kDa (monomer)
SDS-PAGE: 110 kDa, reducing conditions
Protein length
Ala27-Thr343, Thr130Ile
Bio-activity
Measured by its binding ability in a functional ELISA. Immobilized rhIL-13 R alpha 1/Fc Chimera at 4 μg/mL (100 μL/well) can bind rhIL-13 with a linear range of 1-100 ng/mL. Optimal dilutions should be determined by each laboratory for each application.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 100 μg/mL in sterile PBS.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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