Product Overview
Recombinant human IL2 (NP_000577.2, with mutations Leu 38 Met, Leu 39 Ser, Cys 145 Ala) (Ala21-Thr153) was expressed.
Description
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).
Form
Lyophilized from sterile 30% CAN, 0.1% TFA, 5 % trehalose, 5% mannitol and 0.01% Tween80.
