Product Overview
Recombinant IL23A (NP_057668.1) (Met1-Pro189) was fused with a polyhistidine tag at the C-terminus, constructed the plasmid 1; Recombinant p40 subunit of human IL12, termed as IL12B (NP_002178.2) (Met1-Ser328) was fused with a polyhistidine tag at the C-terminus, constructed the plasmid 2. The two plasmids were co-expressed and the IL23 heterodimer was purified.
Description
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Form
Lyophilized from sterile PBS, 10% Glycerol, pH7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
