Recombinant Human IL4 Protein, Tag Free
Product Description
Cat
IMP-6721
Official Symbol
IL4
Product Overview
Recombinant human Interleukin-4/IL4 protein without tag was produced in E. coli.
Description
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Expression System
E. coli
Species
Human
Tag
Tag free
Form
Presentation State: Purified
State: Lyophilized purified protein.
Buffer System: PBS without stabilizer.
Molecular Mass
15 kDa
Endotoxin
< 0.1 ng/μg (1 EU/μg)
Purity
> 98% by SDS-PAGE and HPLC analyses.
Storage
Store lyophilized at 2-8 centigrade for 6 months or at -20 centigrade long term. After reconstitution store the antibody undiluted at 2-8 centigrade for one month or (in aliquots) at -20 centigrade long term. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Reconstitution
The lyophilized IL-4 is soluble in water and most aqueous buffers. Restore in water to a concentration of 100 ng/ml. This solution can be diluted into water or other buffered solutions or stored at -20 centigrade for future use.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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