Recombinant Human IL7R Protein (Gln21-Asp239), C-hFc-tagged
Product Description
Cat
IMP-10443
Official Symbol
IL7R
Product Overview
Recombinant human IL-7R alpha/CD127 protein (Gln21-Asp239) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Chinese Hamster Ovary cell line.
Description
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Expression System
CHO
Species
Human
Tag
C-hFc
Predicted N Terminal
Glu21
Form
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Molecular Mass
Predicted Molecular Mass: 54 kDa
SDS-PAGE: 78-100 kDa, under reducing conditions
Protein length
Gln21-Asp239
Bio-activity
Measured by its binding ability in a functional ELISA. In the presence of 100 ng/mL of Recombinant Human IL-7, Recombinant Human IL-7R alpha/CD127 (Extracellular Domain) Fc Chimera binds with an ED50 of 5-30 ng/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 500 μg/mL in PBS.
SDS-PAGE
SDS-PAGE

Bioactivity-ELISA 1
Binding Activity

Measured by its binding ability in a functional ELISA. In the presence of 100 ng/mL of Recombinant Human IL-7, Recombinant Human IL-7R alpha/CD127 (Extracellular Domain) Fc Chimera binds with an ED50 of 5-30 ng/mL.

Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

Online Inquiry
Contact Info
Phone
  • 1-631-559-9269
    1-516-512-3133
Fax
  • 1-631-938-8127
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