Description
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human Notch-1 Fc Chimera is immobilized at 1.00 μg/mL (100 μL/well), Biotinylated Recombinant Human Jagged 1 Fc Chimera Avi-tag Protein binds with an ED50 of 0.500-2.50 μg/mL.
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
