Recombinant Human KIR2DL4 Protein (24-242aa), C-hIgG-His-Tagged
Product Description
Cat
IMP-9450
Official Symbol
KIR2DL4
Product Overview
Recombinant human KIR2DL4 protein, fused to hIgG-Histag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Description
KIR2DL4, also known as killer cell immunoglobulin-like receptor 2DL4, is a member of the killer cell Ig-like receptor (KIR) family. KIR proteins with the long cytoplasmic domain transduce inhibitory signals via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. This protein induces NK cells to produce IFN-gamma and stimulation with IL-2 upregulates cell surface expression on CD56dim cells and leads to the inhibition of the cytolytic NK cell function.
Expression System
Baculovirus
Species
Human
Tag
C-hIgG-His
Form
Liquid in Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Molecular Mass
51 kDa (458 aa)
Protein length
24-242
AA Sequence
HVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH
Endotoxin
< 1 EU/μg of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Applications
SDS-PAGE
Notes
Note: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage
Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration
0.25 mg/mL (determined by absorbance at 280nm)
SDS-PAGE
SDS-PAGE

3 μg by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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