Description
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D-therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis.
Form
Lyophilized from sterile 20mM Tris, 300mM NaCl, 10%glycerol, pH 8.0, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human NKG2D consists of 157 amino acids and has a calculated molecular mass of 18.4 kDa. As a result of glycosylation, the apparent molecular mass of human NKG2D is approximately 22.6 kDa in SDS-PAGE under reducing conditions.
