Recombinant Human LAG3 Protein, No Tag
Product Description
Cat
IMP-4788
Official Symbol
LAG3
Product Overview
Recombinant human LAG3 (P18627) (Met1-Arg440) was expressed with an initial Met.
Description
LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.
Expression System
HEK293
Species
Human
Tag
No Tag
Predicted N Terminal
Leu 23
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human LAG3 consists 418 amino acids and predicts a molecular mass of 45.3 kDa.
Protein length
Met1-Arg440
Endotoxin
< 1.0 EU/μg of the protein as determined by the LAL method
Purity
> 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

HPLC

97.2% as determined by SEC-HPLC Analysis

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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