Recombinant Human LATS2 Protein (Met1-Ala237), N-His-tagged

Product Description

Cat

IMP-7704

Official Symbol

LATS2

Product Overview

Purified recombinant protein of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), Met1-Ala237, with N-terminal HIS tag, expressed in E. coli.

Description

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Expression System

E. coli

Species

Human

Tag

N-His

Form

25mM Tris, pH 8.0, 150mM NaCl, 10% glycerol

Molecular Mass

25.8 kDa

Protein length

Met1-Ala237

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining.

Storage

Store at -80 centigrade.
Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Concentration

> 50 μg/mL as determined by microplate BCA method.

Data Sheet MSDS

Datasheet MSDS

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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