Recombinant Human LEP Protein, Tag free
Product Description
Cat
IMP-8567
Official Symbol
LEP
Product Overview
Human LEP (P41159, 22 a.a.-167 a.a.) partial recombinant protein expressed in E. coli.
Description
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
Expression System
E. coli
Species
Human
Tag
Tag free
Form
Lyophilized from PBS. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.
Molecular Mass
16 kDa
Protein length
22-167
AA Sequence
VPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
Endotoxin
< 1 EU/μg of protein by LAL method
Purity
> 97% as analyzed by SDS-PAGE; > 97% as analyzed by HPLC.
Applications
Functional Study; SDS-PAGE
Storage
Store at 4 to 8 centigrade for 1 week. For long term storage store at -20 to -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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