Recombinant Human LILRB2 Protein, C-hFc-tagged
Product Description
Cat
IMP-1314
Official Symbol
LILRB2
Product Overview
Recombinant human LILRB2 (AAH36827.1) (Met1-Val461) was expressed with the Fc region of human IgG1 at the C-terminus.
Description
ILT4, also known as LILRB2, is a member of the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for the ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Expression System
HEK293
Species
Human
Tag
C-hFc
Predicted N Terminal
Gln 22
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human LILRB2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 681 amino acids and has a predicted molecular mass of 74.8 kDa. The apparent molecular mass of the protein is approximately 93 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Protein length
Met1-Val461
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method.
Purity
> 85 % as determined by SDS-PAGE
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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