Recombinant Human LILRB5 Protein (Gly24-Gly458), C-hFc-tagged
Product Description
Cat
IMP-9588
Official Symbol
LILRB5
Product Overview
Recombinant human LILRB5/CD85c/LIR-8 protein (Gly24-Gly458) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Human embryonic kidney cell.
Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.
Expression System
HEK293
Species
Human
Tag
C-hFc
Predicted N Terminal
Gly24
Form
Lyophilized from a 0.2 μm filtered solution in PBS.
Molecular Mass
Predicted Molecular Mass: 74 kDa
SDS-PAGE: 85-105 kDa, under reducing conditions
Protein length
Gly24-Gly458
Bio-activity
Measured by its binding ability in a functional ELISA. When Recombinant Human LILRB5/CD85c/LIR-8 Fc Chimera is immobilized at 0.5 μg/mL (100 μL/well), Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 binds with an ED50 of 0.03-0.24 μg/mL.
Endotoxin
<0.10 EU/μg of the protein by the LAL method.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
Notes
Disulfide-linked homodimer
Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution
Reconstitute at 500 μg/mL in PBS.
SDS-PAGE
SDS-PAGE

Bioactivity-ELISA 1
Binding Activity

Measured by its binding ability in a functional ELISA. When Recombinant Human LILRB5/CD85c/LIR-8 Fc Chimera is immobilized at 0.5 μg/mL (100 μL/well), Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 binds with an ED50 of 0.03-0.24 μg/mL.

Data Sheet MSDS
Datasheet MSDS
For research or industrial raw materials, not for personal medical use!

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