Recombinant Human LPAL2 Protein, C-mFc-tagged

Product Description

Cat

IMP-4809

Official Symbol

LPAL2

Product Overview

Recombinant human LPAL2 (Q16609) (Met1-Ala132) was expressed with the Fc region of mouse IgG1 at the C-terminus.

Description

LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a)-like 2 (LPAL2), and the lipoprotein (a) (LPA) gene cluster, which encodes apolipoprotein (a) [apo (a)] of the lipoprotein (a) [Lp (a)] lipoprotein particle, have been suggested to contribute to the risk of coronary artery disease (CAD). Recent genome-wide association studies have identified that genetic variants in the SLC22A3-LPAL2-LPA gene cluster influence plasma lipoprotein(a) [Lp(a)] concentration.

Expression System

HEK293

Species

Human

Tag

C-mFc

Predicted N Terminal

Gly 22

Form

Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.

Molecular Mass

The recombinant human LPAL2/mFc comprises 345 amino acids and has a predicted molecular mass of 38.9 kDa. The apparent molecular mass of the protein is approximately 48.2 and 42.7 kDa in SDS-PAGE under reducing conditions.

Protein length

Met1-Ala132

Endotoxin

< 1.0 EU/μg of the protein as determined by the LAL method

Purity

> 80 % as determined by SDS-PAGE

Storage

Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SDS-PAGE

Data Sheet MSDS

Datasheet MSDS

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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