Recombinant Human LY75 Protein, C-His-tagged
Product Description
Cat
IMP-1345
Official Symbol
LY75
Product Overview
Recombinant human LY75 (NP_002340.2) (Ala32-Gly1664) was expressed with a polyhistidine tag at the C-terminus.
Description
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s and OV2008), by directing epithelial-to-mesenchymal transition (EMT) associated with reduced capacity for in vivo EOC cell colonization, as similar/identical signaling pathways were reversely regulated, when compared to mesenchymal LY75 knockdown EOC cells. Diseases associated with LY75 include Pneumonic Plague and Adenoiditis.
Expression System
HEK293
Species
Human
Tag
C-His
Predicted N Terminal
Ala 32
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human LY75 consists 1644 amino acids and predicts a molecular mass of 189.7 kDa.
Protein length
Ala32-Gly1664
Endotoxin
< 1.0 EU/μg protein as determined by the LAL method.
Purity
> 90 % as determined by SDS-PAGE.
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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