Recombinant Human MDM2 Protein (Gln119-Leu438), N-His-tagged
Product Description
Cat
IMP-7744
Official Symbol
MDM2
Product Overview
Purified recombinant protein of Human Mdm2 p53 binding protein homolog (mouse) (MDM2), transcript variant MDM2, Gln119-Leu438, with N-terminal HIS tag, expressed in E. coli.
Description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Expression System
E. coli
Species
Human
Tag
N-His
Form
25mM Tris, pH 8.0, 150mM NaCl, 10% glycerol
Molecular Mass
35.9 kDa
Protein length
Gln119-Leu438
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining.
Storage
Store at -80 centigrade.
Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Concentration
> 50 μg/mL as determined by microplate BCA method.
Data Sheet MSDS
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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