Product Overview
Recombinant protein of human c-mer proto-oncogene tyrosine kinase (MERTK), residues 21-505aa, with C-terminal DDK tag, expressed in sf9.
Description
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
