Recombinant Human NECTIN4 Protein, C-His-tagged
Product Description
Cat
IMP-4837
Official Symbol
NECTIN4
Product Overview
Recombinant human NECTIN4 (NP_112178.2) (Met1-Ser349) was expressed with a polyhistidine tag at the C-terminus.
Description
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
Expression System
HEK293
Species
Human
Tag
C-His
Predicted N Terminal
Gly 32
Form
Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
Molecular Mass
The recombinant human NECTIN4 consists of 329 amino acids and predicts a molecular mass of 35.6 kDa.
Protein length
Met1-Ser349
Endotoxin
< 1.0 EU/μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC.
Storage
Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
SDS-PAGE
SDS-PAGE

HPLC

99.2% as determined by SEC-HPLC Analysis

Data Sheet MSDS
For research or industrial raw materials, not for personal medical use!

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